Does Doctor Strange in the Multiverse of Madness mean the end of the Scarlet Witch?

Definitely not. There are a lot of reasons why I think that Wanda is returning, one of them being Elizabeth Olsen, the actress for Wanda, supposedly signed a seven year contract with Marvel. Also, we never even see her die, we see a flash of red while a mountain is falling, we don’t know if she shielded, or teleported out of there or anything. And now with the multiverse, the main 616 Wanda might of died but there are still tons of variants throughout the multiverse, we already saw one in M.O.M. Furthermore, the only reasons characters have died so far is because the actors wanted to move on, Elizabeth Olsen definitely doesn’t want to move on, she loves Marvel and Marvel fans and she wants to keep playing Wanda for a long time. Lastly, Wanda is one of, if not the most, popular characters in the MCU right now, they won’t kill her off yet. They will mostly likely give her a redemption arc then he her die in Secret Wars.